After running with all of the features enabled on a VM for a week I noticed that Forefront started to pickup random viruses being written to the root of the C-drive. Every time the filename was BzEngineTempFile followed by some number and a .dk file extension. After some digging the Space Reclamation feature within Diskeeper is actually writing temporary files with all 0’s to the root of the volume where Space Reclamation is occurring. However antivirus products (Forefront & McAfee have been confirmed so far) trigger a random virus as the source.